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dc.contributor.author Lin, Joseph en
dc.contributor.author Miller, Mark J. en
dc.contributor.author Shaw, Andrey S. en
dc.date.accessioned 2012-08-15T16:55:02Z en
dc.date.available 2012-08-15T16:55:02Z en
dc.date.issued 2005-07-18 en
dc.identifier.citation © Lin, Joseph, Mark Miller, and Andrey Shaw. 2005. Originally published in The Journal of Cell Biology. doi: 10.1083/jcb.200503032. en
dc.identifier.uri http://hdl.handle.net/10211.1/1517 en
dc.description © Lin, Joseph, Mark Miller, and Andrey Shaw. 2005. Originally published in The Journal of Cell Biology. doi: 10.1083/jcb.200503032. en
dc.description.abstract T cells integrate and transduce the key signals necessary to mount an appropriate immune response. To do this, they rely on both secreted factors as well as physical cell– cell contact. Much attention has focused on the organization of proteins at the contact area between a T cell and an antigen-presenting cell, known as the immunological synapse. It has been shown in vitro that proteins segregate into two distinct regions within this contact area, a central area referred to as the c-SMAC, where the T cell receptor and associated signaling molecules are enriched, and a peripheral region called the p-SMAC containing LFA-1 and the scaffolding protein talin. Whether or not these structures form in vivo and how they function in T cell activation remain issues of great interest. Here, we review recently published work and propose several possible functions for the role of the c-SMAC in T cell activation. en
dc.language.iso en_US en
dc.publisher The Journal of Cell Biology en
dc.subject T cell en
dc.subject c-SMAC en
dc.title The c-SMAC: Sorting It All Out (or in) en
dc.type Article en
dc.relation.journal The Journal of Cell Biology en
dc.contributor.sonomaauthor Lin, Joseph en


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